St. Nicholas Orthodox Church, DuBois, PA began as a mission in 1978 under the spiritual guidance of His Eminence, Archbishop Job of Chicago, who was then Rector of St. John the Baptist Church, Black Lick, PA. Services were held in various churches and buildings by Deanery clergy until the parish found its present home. Through the hard labor of this small group, generous gifts and loans from the Archdiocese of Western Pennsylvania (OCA), sister parishes, and pious individuals, St Nicholas Orthodox Mission finally had a home on North Third Street in 1980, along with a full-time parish priest.

In April of 2020, with the assistance of the Archdiocese, the parishioners of St. Nicholas purchased the former St. Joseph Roman Catholic Church at 301 South State Street. The current location is accessible with a large social hall for the events the parish conducts throughout the year. Renovations are ongoing to transform the building into beautiful, Orthodox-styled church. (The original location remains as an icon studio and home for Fr. Mark Meholick, our rector, as well as a chapel for select services.)

The parish is combined administratively with Saints Peter and Paul Church, Urey, PA, which is about a 45-minute drive from DuBois. Both parishes are served by Fr. Mark, so the liturgical schedule is shared between the two churches. With the ordination of Fr. Dn. Christopher Meholick in July 2023, Sunday services at St. Nicholas now alternate between Divine Liturgy and Obednitsa with Communion.  Glory to Jesus Christ!